Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Timers in developing systems.

Science (New York, N.Y.)

|March 2, 1979

Summary

New methods reveal developmental timing in slime mold. Six parallel timers control cell development, offering insights into biological process regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Behavioral studies into the mechanism of eukaryotic chemotaxis.

Journal of chemical ecology·2013

Same author

Cyclic AMP inhibits dedifferentiation in the cellular slime mold Dictyostelium discoideum.

Developmental biology·2010

Same author

Regulation of caldesmon activity by Cdc2 kinase plays an important role in maintaining membrane cortex integrity during cell division.

Cellular and molecular life sciences : CMLS·2003

Same author

The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans.

Journal of bacteriology·2001

Same author

A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans.

Genetics·2001

Same author

Development and use of complex probes for DNA fingerprinting the infectious fungi.

Medical mycology·2001

Area of Science:

Developmental biology
Cellular morphogenesis
Quantitative biology

Background:

Understanding the genetic and molecular mechanisms that control the timing of developmental events is crucial in developmental biology.
Rate-limiting processes govern the progression through discrete stages in biological development.
Investigating these processes requires robust methodologies to dissect complex biological sequences.

Purpose of the Study:

To propose novel conditional methods for analyzing the number and interactions of rate-limiting processes in developmental sequences.
To apply these methods to study multicellular morphogenesis in Dictyostelium discoideum.
To elucidate the temporal relationships between developmental stages.

Main Methods:

Development of conditional methods based on the temperature sensitivity of biological "timer" pathways.
Application of these methods to monitor discrete stages in the developmental sequence of Dictyostelium discoideum.
Analysis of differential pathway sensitivity to small temperature fluctuations to infer timer relationships.

Main Results:

A tentative scheme for timer relationships in Dictyostelium discoideum morphogenesis was established.
A minimum of six distinct timers were identified, each linked to specific morphological stages.
The majority of these identified timers operate in parallel pathways.

Conclusions:

The proposed conditional methods are effective for dissecting developmental timing mechanisms.
The findings suggest a complex, multi-timer system regulating Dictyostelium discoideum development.
The predominantly parallel nature of these timers offers new perspectives on developmental regulation.

Related Experiment Videos