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Related Experiment Video

Updated: Apr 7, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Intravesical Platelet-Rich Plasma Injection for Refractory Interstitial Cystitis/Painful Bladder Syndrome: A

Gabriel Chahade Sibanto Simões1, Caio de Oliveira2, Lucas Mira Gon2

  • 1State University of Campinas (UNICAMP), Campinas, SP, Brazil. gabrielcssimoes@gmail.com.

International Urogynecology Journal
|April 6, 2026
PubMed
Summary

Platelet-rich plasma (PRP) injections show potential for treating interstitial cystitis/bladder pain syndrome (IC/BPS) in women. While improvements in pain and urinary symptoms were noted, further high-quality research is needed due to limited evidence.

Keywords:
Interstitial CystitisIntravesical AdministrationPlatelet-Rich Plasma

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Area of Science:

  • Urology
  • Regenerative Medicine

Background:

  • Interstitial cystitis/bladder pain syndrome (IC/BPS) significantly impacts women's quality of life.
  • Current treatment options for refractory IC/BPS have limitations.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of intravesical platelet-rich plasma (PRP) injections for women with IC/BPS.
  • To evaluate PRP's impact on pain, urinary symptoms, and bladder function.

Main Methods:

  • Systematic review and meta-analysis following PRISMA guidelines.
  • Included quasi-experimental, uncontrolled, non-randomized studies.
  • Assessed outcomes including pain (VAS), symptom scores, urinary frequency, nocturia, and urodynamic parameters.

Main Results:

  • A mean success rate (Global Response Assessment ≥2) of 48% was observed.
  • Statistically significant improvements in pain scores, urinary frequency, and nocturia were noted.
  • Positive trends in bladder function, including increased Qmax and voided volume, were identified.

Conclusions:

  • Intravesical PRP injections show promise for refractory IC/BPS, with potential benefits for pain and urinary symptoms.
  • Current evidence is limited by the low quality of included studies (uncontrolled, non-randomized).
  • High-quality randomized controlled trials are essential to confirm PRP efficacy and establish its clinical role.