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Marine-derived Bioactives as Novel Interventions for Cardiovascular Disorders.

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Marine bioactive compounds show promise for cardiovascular health, offering natural alternatives to synthetic drugs. Further research and sustainable practices are needed to harness their full therapeutic potential for heart disease.

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Area of Science:

  • Marine Biology
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Cardiovascular diseases (CVDs) are a major global health concern.
  • Marine natural products offer potential cardioprotective, anti-inflammatory, and antioxidant benefits.
  • These compounds present safer alternatives to conventional cardiovascular medications.

Purpose of the Study:

  • To review marine-derived bioactive compounds with potential cardiovascular benefits.
  • To analyze their chemical properties, pharmacological activities, and mechanisms of action.
  • To assess their therapeutic potential for CVDs.

Main Methods:

  • Narrative review of peer-reviewed literature from the past two decades.
  • Searched key databases (PubMed, Scopus, Web of Science).
  • Focused on studies detailing chemical characterization, pharmacological activities, and mechanistic insights.

Main Results:

  • Marine organisms yield diverse bioactives: polysaccharides, polyphenols, carotenoids, peptides, proteins, and essential fatty acids.
  • Specific compounds (e.g., exopolysaccharides, phlorotannins, EPA, astaxanthin) show significant antioxidant, lipid-lowering, anti-inflammatory, and vascular-protective effects in preclinical studies.
  • Some marine-derived agents, like omega-3-acid ethyl esters, are in clinical trials for CVD management.

Conclusions:

  • Marine compounds possess favorable safety profiles and structural diversity for cardioprotective therapies.
  • Challenges include variability in extraction, limited human trials, and ecological sustainability.
  • Translational research and standardized protocols are crucial for clinical application.