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Updated: Apr 8, 2026

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LED red light for atrophy and microcirculation in pathologic myopia (RAMP): study design and protocol for a

Juzhao Zhang1,2,3, Jun Yu4, Xiaojuan Wang5

  • 1Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China.

BMJ Open
|April 6, 2026
PubMed
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This summary is machine-generated.

Low-level red light therapy shows promise for treating pathologic myopia (PM) by improving choroidal vascularity. This study investigates its safety and efficacy in delaying vision loss in PM patients.

Area of Science:

  • Ophthalmology
  • Medical Devices
  • Regenerative Medicine

Background:

  • Pathologic myopia (PM) is a significant cause of irreversible blindness globally, with limited treatment options.
  • Repeated low-level red light (RLRL) therapy effectively slows myopia progression in children but hasn't been studied in PM.
  • This research explores RLRL's potential in managing PM, a condition characterized by progressive vision loss.

Purpose of the Study:

  • To assess the impact of RLRL therapy on choroidal vascular density and thickness in PM patients.
  • To evaluate the safety and efficacy of RLRL in preventing the progression of fundus atrophic lesions in PM.
  • To explore novel therapeutic avenues for a leading cause of irreversible blindness.

Main Methods:

  • A prospective, randomized, controlled trial involving 158 PM patients (aged 18-55).
Keywords:
Medical retinaMyopiaTHERAPEUTICS

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  • Participants were randomized to receive either RLRL therapy (660 nm, 65 mW/cm², twice daily, 5 days/week for 12 months) or a sham treatment.
  • The primary outcome was the change in choroidal vascular density and choroidal vessel volume index after 12 months.

    • Main Results:

    • The study is ongoing; results are pending.
    • The primary outcome measure is the change in choroidal vascular density and choroidal vessel volume index at 12 months.
    • Secondary outcomes will include the progression of fundus atrophic lesions.

    Conclusions:

    • RLRL therapy is being investigated as a potential treatment for pathologic myopia.
    • Further research is needed to confirm the long-term benefits and safety of RLRL for PM.
    • This trial may offer new hope for preserving vision in patients with PM.