Related Experiment Video
Updated: Aug 7, 2026

A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
Abstract:
When blood is released into the tissues of the lower extremities, it may drift downward under the influence of the force of gravity to produce the influence of the force of gravity to produce pain, edema, redness and heat. A crescent shaped ecchymosis may appear around the malleoli. The relationship between cause and effect may be obscured by a time interval of up to four weeks before conclusive signs are seen. Early differentiation of this condition from that of phlebitis and deep venous thrombosis is necessary. Such differentiation prevents inappropriate and potentially dangerous anticoagulation as well as the disastrous consequences of untreated edema of the legs. With prompt, appropriate treatment, complete recovery can be expected. If treatment is delayed, permanent damage to the leg can result.
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology

