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LGR5: from stem cell marker to therapeutic target.
Peyton C High1, Maya G Cappellino1, Tiffani A Blackburn1
1Center for Translational Cancer Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a key marker in cancer stem cells, driving tumor growth and resistance. Targeting LGR5 shows promise for effective cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a marker for normal and cancer stem cells.
- LGR5 promotes cancer cell plasticity, contributing to tumorigenesis, metastasis, and therapeutic resistance.
- LGR5 signaling pathways, including Wnt/β-catenin, are crucial but not fully understood.
Purpose of the Study:
- To review the cancer-related functions of LGR5.
- To explore therapeutic strategies targeting LGR5.
- To provide insight into LGR5's role in cancer progression.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of LGR5's role in cancer stem cell biology.
- Evaluation of LGR5-targeting therapies.
Main Results:
- LGR5 is implicated in key cancer processes like metastasis and drug resistance.
- Understanding LGR5 mechanisms can reveal insights into cancer progression.
- LGR5-targeting therapies demonstrate promising efficacy and tolerability.
Conclusions:
- LGR5 plays a significant role in cancer progression and stemness.
- Targeting LGR5 offers a promising therapeutic avenue for various cancers.
- Further research into LGR5 signaling is essential for developing novel treatments.
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