Related Experiment Video
Updated: Apr 8, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Association Between Statin Use and Non-Melanoma Skin Cancer Risk: A Distributed Network Analysis of 11 Real-World
Jiyoon An1, Man S Kim2, Yoonsung Lee2
1Kyung Hee University College of Medicine, Seoul, Korea.
Background:
Given the dual potential of statins to act as both carcinogenic and antineoplastic agents, evidence from previous investigations into statin use and the risk of nonmelanoma skin cancer (NMSC) remains inconclusive.
Objective:
To demonstrate the impact of statin exposure on the NMSC risk in Korean patients.
Methods:
We carried out a multicenter cohort study based on electronic health record data aggregated from 11 Korean hospitals. Patients with hyperlipidemia who had been taking antilipidemic agents, including statins were included in this study. We applied 1:1 propensity score matching to create balanced cohorts and used Cox regression to assess the hazard ratio (HR) for NMSC.
Results:
A total of 18,579 statin users and a matched number of non-users were included across 11 databases. Statin use showed no significant association with an increased risk of NMSC (HR, 1.03; 95% confidence interval, 0.75-1.43). Subgroup analyses of drug exposure, age, and sex depicted no significant HR trends.
Conclusion:
Statin exposure demonstrated no significant association with NMSC development in Korean patients with hyperlipidemia.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Statistical Methods for Analyzing Epidemiological Data
Cancer Survival Analysis
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
