Exercise-myokine relationships in osteoarthritis

Area of Science:

• Biochemistry
• Exercise Physiology
• Rheumatology

Background:

• Osteoarthritis (OA) pathogenesis involves biomechanics, metabolism, and inflammation.
• Current OA treatments have limitations and side effects.
• Novel strategies targeting pathological networks are needed.

Purpose of the Study:

• To review the
• exercise-myokine-joint
• regulatory axis in OA.
• To explore the molecular basis and translational potential of this network.
• To provide theoretical support for myokine-targeted OA interventions.

Main Methods:

• Systematic review of the literature.
• Analysis of the role of myokines in OA.
• Examination of exercise parameters and their effect on myokine secretion.

Main Results:

• Exercise modulates OA via the
• exercise-myokine-joint
• axis.
• Myokines regulate cartilage metabolism, inflammation, and bone remodeling.
• Exercise parameters correlate with myokine secretion.

Conclusions:

• The exercise-myokine-OA network offers a breakthrough for OA prevention and treatment.
• This review supports precision interventions targeting myokines.
• Novel pathways for clinical optimization of exercise therapy are identified.