Related Experiment Video
Updated: Apr 8, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma
Shireen S Gohari1,2, Isaac Wasserman1,2, Justine Philteos1,2
1Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

