Related Experiment Video
Updated: Apr 8, 2026
08:05
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
Published on: March 23, 2022
3.1K
Implementation of low-dose buprenorphine induction at a syringe services program.
Maia H Hauschild1, Peyton V Warp2, William H Eger3,4
1Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA. maiahaus@gmail.com.
Addiction Science & Clinical Practice
|April 6, 2026
Summary
Low-dose induction (LDI) shows promise for treating opioid use disorder (OUD) by mitigating withdrawal symptoms, but high follow-up loss in real-world settings requires further study.
Area of Science:
- Addiction Medicine
- Pharmacology
- Public Health
Background:
- Fentanyl complicates opioid use disorder (OUD) treatment, increasing risks like buprenorphine-precipitated opioid withdrawal (BPOW).
- Traditional buprenorphine induction can be difficult for fentanyl users.
- Low-dose induction (LDI) offers a gradual titration method to reduce BPOW risk.
Purpose of the Study:
- To assess the feasibility and acceptability of LDI in a low-barrier syringe services program (SSP).
- To evaluate LDI as an alternative induction method for OUD patients using fentanyl.
Main Methods:
- A mixed-methods prospective cohort study was conducted at an SSP in Miami, Florida.
- A 4-day LDI protocol was offered to 30 OUD patients interested in buprenorphine.
- Outcomes included urine drug screens, symptom surveys, and qualitative interviews within four weeks.
Main Results:
- 53% of participants returned for follow-up.
- 56% of those followed up tested positive for buprenorphine.
- Most participants reported LDI success and acceptability, citing reduced withdrawal and increased autonomy.
Conclusions:
- LDI is perceived as acceptable and empowering, despite low objective induction rates.
- High participant attrition and environmental instability limit conclusions.
- Further research is needed to optimize LDI protocols and address barriers to treatment success.
Keywords:
AddictionBuprenorphineFentanylLow-dose inductionMicrodoseOpioid use disorderSyringe services programMore Related Videos
Related Concept Videos
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
1.5K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.5K
01:24Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
376
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
376
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
424
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
424
01:22Drug Delivery: Miscellaneous Routes
1.0K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.0K
01:26Oral Drug Delivery Systems: Continuous-Release Systems
226
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
226
01:17Drug Dependence
1.9K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.9K