Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

456
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
456
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

415
Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
415
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

1.7K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.7K
Angina V: Nursing Management01:20

Angina V: Nursing Management

525
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
525
Exercise Stress Test01:26

Exercise Stress Test

2.0K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
2.0K
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

935
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
935

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring Inflation-Related Public Discourse Relevant to Social Determinants of Health Using Social Media Data.

International journal of environmental research and public health·2026
Same author

Diagnostic yield of the one-year surveillance colonoscopy after curative colorectal cancer resection.

International journal of colorectal disease·2026
Same author

Interpretable machine learning for rare events: an inverse probability weighted application to understanding glucagon-like peptide-1 receptor agonists use and incident alcohol-related disorder.

Alcohol and alcoholism (Oxford, Oxfordshire)·2026
Same author

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
Same author

Role of Repeat Preoperative Endoscopy in Colorectal Cancer: Patients' Perspectives.

Cureus·2026
Same author

Incidence and Outcomes of Unstable Angina in Patients with Low High-Sensitivity Cardiac Troponin I Values-A Substudy of the RACE-IT Trial.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Apr 8, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.1K

Federated Meta-Analysis of HEART Score Performance for Emergency Department Chest Pain.

Hao Wang1, Eric Chou2, Richard D Robinson3

  • 1Department of Emergency Medicine, JPS Health Network, Integrative Emergency Services, Fort Worth, Texas, USA.

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
|April 7, 2026
PubMed
Summary

Federated meta-analysis accurately estimated the HEART score's performance for predicting major adverse cardiovascular events (MACE30) across multiple emergency departments. This privacy-preserving method enables scalable multicenter evaluations of risk stratification tools.

Keywords:
HEARTchest painemergency departmentfederated meta‐analysis

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.9K
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

3.0K

Related Experiment Videos

Last Updated: Apr 8, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.1K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.9K
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

3.0K

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Health Informatics

Background:

  • Multicenter studies evaluating emergency department (ED) risk stratification tools face challenges with patient-level data sharing.
  • The HEART score is a widely used tool for assessing cardiovascular risk in patients presenting to the ED.
  • Accurate performance estimates are crucial for effective clinical decision-making.

Purpose of the Study:

  • To evaluate if a federated diagnostic meta-analytic approach can yield performance estimates comparable to centralized analysis for the HEART score.
  • To assess the HEART score's ability to predict 30-day major adverse cardiovascular events (MACE30) using a federated approach.
  • To determine the feasibility of privacy-preserving, scalable multicenter evaluation of ED risk stratification tools.

Main Methods:

  • A retrospective, multicenter observational study involving six EDs from January 2020 to December 2023.
  • Adult patients with chest pain and a documented HEART score were included; MACE30 included myocardial infarction, revascularization, or all-cause mortality.
  • Diagnostic performance was assessed using federated bivariate random-effects meta-analysis of site-level 2x2 tables, compared against centralized patient-level analysis.

Main Results:

  • The study analyzed 57,906 ED encounters, with MACE30 occurring in 2.2%.
  • Federated meta-analysis showed the HEART score had high specificity and negative predictive value, with modest between-site variability (HSROC AUC 0.759).
  • Performance estimates from federated analysis closely aligned with centralized analysis (AUROC 0.785), indicating small, clinically modest differences.

Conclusions:

  • Federated diagnostic meta-analysis provides HEART score performance estimates comparable to centralized patient-level data analysis.
  • This federated approach enables scalable, privacy-preserving multicenter evaluations of ED risk stratification tools.
  • The method effectively accommodates practice setting heterogeneity and variations in outcome prevalence.