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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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Radiotheranostics With Nanoparticles: Precision Targeting in Receptor-Overexpressing Tumors.

Evalyne J Cheruiyot1,2, David M Wanjeh1,2, John K Birir1

  • 1Institute of Nuclear Science & Technology, University of Nairobi, Nairobi, Kenya.

Journal of Labelled Compounds & Radiopharmaceuticals
|April 7, 2026
PubMed
Summary
This summary is machine-generated.

Nanoparticles offer advanced cancer theranostics by combining imaging and therapy. Receptor-targeted nanocarriers show promise for precision oncology, but clinical translation remains a challenge.

Keywords:
cancer therapeuticsnanomedicinenanoparticlesprecision oncologyradiotheranosticsreceptor‐overexpressing tumorstargeted drug delivery

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Area of Science:

  • Oncology
  • Nanotechnology
  • Radiochemistry

Background:

  • Cancer management is a significant medical challenge.
  • Nanotechnology offers innovative solutions for early diagnosis, therapy, and monitoring of cancer.
  • Nanoparticles (NPs) are advancing precision medicine through theranostics, integrating diagnostics and targeted therapy.

Purpose of the Study:

  • To review the current state of receptor-targeted radionanoparticles for cancer theranostics.
  • To examine the design, functionalization, and targeting strategies of these NPs.
  • To discuss their clinical translational potential and challenges.

Main Methods:

  • Review of current literature on receptor-targeted radionanoparticles.
  • Analysis of NP design, biocompatible materials, and ligand functionalization.
  • Examination of radioisotope loading for imaging and therapeutic applications.

Main Results:

  • Receptor-targeted NPs show promise for precise cancer diagnosis and therapy.
  • Functionalization with specific ligands enhances targeting of cancer cells.
  • Radiolanoparticles integrate imaging and therapeutic capabilities for theranostics.

Conclusions:

  • Receptor-targeted radionanoparticles represent a significant advancement in precision oncology.
  • Further research and clinical translation are needed to realize their full potential.
  • Tumor markers play a crucial role in guiding NP delivery and enhancing therapeutic efficacy.