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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

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Radiomics-Based Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic Patients Using

Celine Sin1,2,3, Martin Luther Watzenboeck4,5, Eugenia Iofinova1,6

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A new CT-based radiomics model accurately predicts hepatic venous pressure gradient (HVPG) in cirrhosis patients. This non-invasive method aids in risk stratification for liver-related events, improving patient management.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatology

Background:

  • Cirrhosis management requires accurate assessment of portal hypertension.
  • Hepatic venous pressure gradient (HVPG) is a key indicator but invasive.
  • Non-invasive methods for HVPG assessment are needed.

Purpose of the Study:

  • To develop and validate a CT-based radiomics model to assess HVPG.
  • To predict liver-related events (LRE) in cirrhosis patients using this model.

Main Methods:

  • Retrospective study of 357 cirrhosis patients and 120 controls.
  • CT-based radiomics model developed using random forest and Bayesian optimization.
  • Model validated internally and externally for HVPG prediction and LRE risk stratification.

Main Results:

  • The radiomics model (radio-HVPG) correlated well with invasive HVPG (r=0.63 internal, r=0.62 external).
  • Radio-HVPG accurately identified clinically significant portal hypertension (CSPH).
  • Radio-HVPG predicted LRE independently and performed similarly to invasive HVPG.

Conclusions:

  • CT-based radiomics can accurately predict HVPG in cirrhosis.
  • This non-invasive radiomics model enables risk stratification for LRE.
  • Radiomics offers a promising tool for managing cirrhosis patients.