Bibliometric analysis of programmed death ligand-1 positron emission tomography probe research: development,...

This study aims to provide a comprehensive bibliometric analysis of the research landscape, technological evolution, and future trends in the field of programmed death ligand-1 (PD-L1) PET probes.

Publications related to PD-L1 PET probes from 2010 to 28 August 2025, were retrieved from the Web of Science Core Collection. Bibliometric analysis and visualization were performed using CiteSpace, VOSviewer, and Bibliometrix R package.

Our analysis included 389 publications. The field has experienced exponential growth since 2016. China and the USA were the leading contributors, with the latter demonstrating superior citation impact due to seminal early studies. The technological evolution reveals a clear paradigm shift from large antibody-based probes towards small and medium-sized molecules, driven by the demand for improved clinical translation. 68 Ga and 89 Zr are the most commonly used radionuclides at present, suitable for small-to-medium molecules and antibody-based probes, respectively. Peptides and nanobodies are the most promising molecular scaffold, balancing imaging performance and clinical practicality. Cooccurrence and burst detection analysis identified nonsmall-cell lung cancer, antibody, nanobody, PET, and PD-1/PD-L1 as the top trending topics.

This bibliometric analysis delineates the current state, evolutionary patterns, and prospective research avenues in PD-L1 PET probe research, highlighting the advancements in noninvasive immuno-imaging and offering a data-driven perspective for researchers.