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Updated: Apr 8, 2026

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
Published on: December 1, 2023
Sulfur-centered non-covalent interactions: emerging themes and challenges from rotational spectroscopy
Jiaxin Tang1, Wen Wen1, Alberto Lesarri2
1School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Rd. 55, 401331 Chongqing, China. fengg@cqu.edu.cn.
None:
Non-covalent interactions involving sulfur are linked to a myriad of chemical and biological processes, playing a crucial role in biochemistry, supramolecular chemistry and crystal engineering. However, precise determination of the energetic and structural properties of these weak, less directional and dispersion-controlled interactions remains a formidable challenge both experimentally and theoretically. In this context, the unique structural sensitivity of microwave spectroscopy is of great significance for the study of jet-cooled clusters, providing a comprehensive molecular description that serves as a testbed for computational models. This review highlights recent advancements in the exploration of sulfur-centered non-covalent interactions through rotational spectroscopy. The selected examples emphasize the isotopic-sensitive high-resolution advantage of microwave spectroscopy for the structural and energetic assessment of non-covalent interactions. These insights hold the potential to facilitate the understanding and application of such weak interactions in the fields of biochemistry, supramolecular chemistry, and crystal engineering.
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