Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

13.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
13.4K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

72
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
72
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.7K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.7K
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

2.6K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
2.6K
Pharmacodynamic Models: Overview01:27

Pharmacodynamic Models: Overview

92
Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...
92
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model01:29

Pharmacodynamic Models: Direct Effect Model and Indirect Response Model

123
Pharmacodynamic models are essential tools in understanding the relationship between drug concentrations and their effects on biological systems. By characterizing the dynamics of drug action, these models guide dose selection, optimize therapeutic efficacy, and inform the development of new drugs. Two major classes of pharmacodynamic models include direct effect and indirect response models.Direct Effect ModelsDirect effect models describe the immediate relationship between drug concentration...
123

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foodborne sources of antimicrobial-resistant Escherichia coli in community-acquired urinary tract infections in Bangladesh.

Communications medicine·2026
Same author

First-principles study of rare-earth-free Cs<sub>4</sub>SrI<sub>6</sub>:Tl, a zero-dimensional halide perovskite for scintillation applications.

RSC advances·2026
Same author

Strengthening Biosafety and Biosecurity Status in Bangladesh: A Sustainable Approach.

Applied biosafety : journal of the American Biological Safety Association·2026
Same author

Clonal dynamics of HIV-infected and uninfected T cells.

EBioMedicine·2026
Same author

Distance Learning-Based Prototypical Network With Multi-Domain Adaptation for Few-Shot Hyperspectral Medical Image Classification.

IEEE journal of biomedical and health informatics·2026
Same author

Anatomical 3D Reconstruction of Murine Lymph Nodes for Visualization, Quantitation, and Numerical Simulation.

bioRxiv : the preprint server for biology·2025
Same journal

Promoting Healthier Communities Through the Delaware State Health Improvement Plan.

Delaware journal of public health·2026
Same journal

Virtual Nurse-Led Patient Education: A Public Health Opportunity.

Delaware journal of public health·2026
Same journal

Challenges Impacting Delaware Dental Professionals' Capacity to Care for Patients with Disabilities.

Delaware journal of public health·2026
Same journal

20 Years of the Delaware Healthy Mother & Infant Consortium: Embracing the Celebration, Heeding the Call to Action.

Delaware journal of public health·2026
Same journal

Interprofessional Collaboration in the Obstetrical Emergency Department: Enhances Nursing Job Satisfaction While Improving Care of the Laboring Patient.

Delaware journal of public health·2026
Same journal

AI for Good: Utilizing Machine Learning Tools to Navigate Late Onset Neonatal Sepsis.

Delaware journal of public health·2026
See all related articles

Related Experiment Video

Updated: Apr 8, 2026

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.5K

Model-Informed Drug Development: Addressing the Critical Need for Training in the Promising New Field.

Yasaman Moghadamnia1, Ryan Zurakowski2, Mohammad Aminul Islam1

  • 1Department of Biomedical Engineering, University of Delaware.

Delaware Journal of Public Health
|April 7, 2026
PubMed
Summary
This summary is machine-generated.

The pharmaceutical industry is adopting advanced modeling like Model-Informed Drug Development (MIDD) and Quantitative Systems Pharmacology (QSP) to improve drug discovery success rates. The University of Delaware now offers a dedicated Master's program in QSP to train scientists for this growing field.

More Related Videos

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

74
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.4K

Related Experiment Videos

Last Updated: Apr 8, 2026

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.5K
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

74
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.4K

Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Computational Biology

Background:

  • Drug discovery success rates remain low (10-20%) due to reductionist approaches.
  • Complex biological networks require advanced modeling for effective drug development.
  • Growing pharmaceutical investment necessitates a skilled workforce in modeling and simulation.

Purpose of the Study:

  • To address the shortage of scientists trained in Model-Informed Drug Development (MIDD) and Quantitative Systems Pharmacology (QSP).
  • To bridge the gap between traditional biomedical engineering curricula and industry demands for advanced modeling skills.
  • To prepare graduates for careers in the pharmaceutical and biotechnology sectors through specialized training.

Main Methods:

  • Integration of MIDD principles into existing graduate biomedical engineering curriculum.
  • Establishment of the first Master's program in Quantitative Systems Pharmacology (QSP) in the United States.
  • Development of structured, industry-aligned training programs focused on advanced modeling and simulation.

Main Results:

  • The University of Delaware's Biomedical Engineering department has proactively addressed the industry's need for MIDD and QSP expertise.
  • A new Master's program in QSP has been launched to provide specialized training.
  • The program aims to equip students with the necessary skills for pharmaceutical and biotechnology careers.

Conclusions:

  • The University of Delaware's initiative directly tackles the workforce shortage in MIDD and QSP.
  • This program provides essential training for optimizing drug development through advanced modeling.
  • Graduates will be prepared to contribute to the expanding pharmaceutical and biotechnology industries.