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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Updated: Apr 8, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Development and Validation of Nomogram Predicting Survival in Resectable Gallbladder Cancer.

Shraddha Patkar1, Tanvi M Shah1, Mufaddal Kazi1

  • 1Department of Surgical Oncology, Tata Memorial Hospital and Homi Bhabha National Institution, Mumbai, India.

Journal of Hepato-Biliary-Pancreatic Sciences
|April 7, 2026
PubMed
Summary
This summary is machine-generated.

A new nomogram accurately predicts survival for gallbladder cancer (GBC) patients undergoing surgery. This tool aids in risk stratification and selecting adjuvant treatments to improve outcomes for this aggressive cancer.

Keywords:
adjuvant treatment selectiongallbladder cancer survivalpredictive nomogram

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Cancer Prognostics

Background:

  • Gallbladder cancers (GBCs) are aggressive malignancies with historically poor prognoses.
  • Accurate survival prediction is essential for personalized treatment strategies in GBC.

Purpose of the Study:

  • To develop and validate a predictive nomogram for overall survival (OS) in patients with resectable GBC.

Main Methods:

  • Retrospective analysis of 1045 patients with resected GBC (2010-2022).
  • Development and internal validation of a nomogram incorporating clinical and pathological factors.
  • Assessment of nomogram performance using Harrell's concordance index and ROC curve analysis.

Main Results:

  • The nomogram integrated age, T stage, N stage, invasion status, CA 19.9, GBC type, and grade.
  • Achieved a Harrell's concordance index of 0.677 and good discriminative ability for 1-, 3-, and 5-year OS.
  • Successfully stratified patients into low-risk and high-risk groups with significantly different median OS.

Conclusions:

  • The developed nomogram shows strong discriminative and risk-stratification capabilities for resectable GBC.
  • It can assist in optimizing adjuvant treatment selection and application.
  • Potential to improve patient outcomes through tailored therapeutic strategies.