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Updated: Apr 8, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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[Lipoprotein(a) and cerebrovascular diseases]
1Yaroslavl State Medical University, Yaroslavl, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 7, 2026
Summary
Elevated lipoprotein(a) levels significantly increase the risk of vascular diseases, including stroke. This finding highlights lipoprotein(a) as a key therapeutic target for secondary stroke prevention and a promising biomarker.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Pathology
Background:
- Lipoprotein(a) is a genetically regulated particle increasingly recognized as an independent risk factor for vascular diseases.
- Evidence confirms its multifaceted role in atherogenesis, vascular calcification, inflammation, and thrombogenesis.
Purpose of the Study:
- To summarize the role of lipoprotein(a) in vascular disease pathogenesis.
- To highlight its significance as a risk factor for cardiovascular and cerebrovascular events.
- To explore its potential as a therapeutic target and biomarker for stroke.
Main Methods:
- Review of epidemiological studies.
- Analysis of genetic studies.
- Examination of pathogenetic mechanism research.
Main Results:
- Elevated lipoprotein(a) levels are independently associated with increased risk of cardiovascular and cerebrovascular events.
- High lipoprotein(a) correlates with higher stroke recurrence and poorer functional outcomes.
- Lipoprotein(a) plays a complex role in multiple aspects of vascular disease.
Conclusions:
- Lipoprotein(a) is a significant, genetically influenced risk factor for vascular diseases.
- It represents a potential therapeutic target for secondary stroke prevention.
- Lipoprotein(a) shows promise as a valuable biomarker in stroke patients.
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