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Updated: Apr 8, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Synthesis of Axially Chiral Styrenes via Pd-Catalyzed Atroposelective C-H Olefination
1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China.
Abstract:
The synthesis and application of new axially chiral skeletons have always been an attractive and important topic in synthetic chemistry. Herein, we developed a Pd(II)-catalyzed atroposelective C-H olefination for the synthesis of axially chiral styrene with N,N-disubstituted amide groups. A broad range of axially chiral styrenes were obtained in good to excellent yields and enantioselectivities (up to 80% yield and 95% ee) under mild conditions. Gram-scale reaction and further transformation reactions also provide a platform for synthetic applications of this method.
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