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Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Pre-Procedural Guidelines for Assessing Blood Pressure01:10

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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
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Related Experiment Video

Updated: Apr 8, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

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Obstetric History Versus Biomarkers: Hypertension Risk Up to 15 Years Postpartum.

Tooba Anwer1, David E Cantonwine2, Ellen W Seely3

  • 1Division of Maternal Fetal Medicine (T.Z.A., T.F.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Hypertension (Dallas, Tex. : 1979)
|April 7, 2026
PubMed
Summary

A history of hypertensive disorders of pregnancy, including preeclampsia, is linked to long-term hypertension risk. However, serum soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratios during pregnancy did not predict this future risk.

Keywords:
blood pressurecardiovascular diseaseheart failurepre-eclampsiapregnancyprevalence

Related Experiment Videos

Last Updated: Apr 8, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.4K

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Health
  • Reproductive Medicine

Background:

  • Serum soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratios can predict severe preeclampsia.
  • The association between pregnancy sFlt-1/PlGF levels and long-term hypertension risk remains unclear.

Purpose of the Study:

  • To investigate the association between sFlt-1/PlGF levels during pregnancy and the long-term risk of developing hypertension.
  • To determine if a history of hypertensive disorders of pregnancy impacts future hypertension risk.

Main Methods:

  • Retrospective cohort study of 993 participants from the LIFECODES biobank (2006-2008).
  • sFlt-1 and PlGF levels measured in the second half of pregnancy.
  • 15-year follow-up using electronic medical records to identify hypertension diagnoses.
  • Adjusted Cox proportional hazard models used to assess risk.

Main Results:

  • A history of gestational hypertension or preeclampsia was significantly associated with developing hypertension later in life (aHR 3.50 and 2.17, respectively).
  • No significant association was found between sFlt-1/PlGF ratios and the hazard of developing hypertension.
  • Mean PlGF levels were significantly higher in participants who remained normotensive compared to those who developed hypertension (546.7 pg/mL vs. 513.7 pg/mL, P=0.008).

Conclusions:

  • A history of hypertensive disorders of pregnancy is a significant predictor of future hypertension.
  • Elevated sFlt-1/PlGF ratios during pregnancy were not associated with long-term hypertension risk.
  • Lower placental growth factor (PlGF) levels were observed in individuals who later developed hypertension.