A nickel-based bipolar electrochemiluminescence platform for glucose detection
Xianchuan Dong1, Yaoxuan Wang1, Jing Sui1
1College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Qingdao 266071, China. zhangfeifei@qdu.edu.cn.
The Analyst
|April 7, 2026
Summary
A new nickel-based sensor offers rapid, non-invasive glucose detection in urine using bipolar electrochemiluminescence (BP-ECL). This low-cost biosensor is ideal for point-of-care testing and home health monitoring.
Area of Science:
- Electrochemistry
- Biosensors
- Analytical Chemistry
Background:
- Glucose monitoring is crucial for managing diabetes and other chronic diseases.
- Current methods can be invasive, costly, or require complex instrumentation.
- Development of accessible and sensitive glucose detection methods is needed.
Purpose of the Study:
- To develop a cost-effective, non-invasive biosensor for rapid glucose detection in urine.
- To utilize nickel-based bipolar electrodes for enhanced electrochemiluminescence (ECL).
- To assess the sensor's performance for point-of-care and home health monitoring.
Main Methods:
- Fabrication of nickel-based multichannel bipolar electrodes.
- Utilizing glucose oxidase for hydrogen peroxide production.
- Measuring luminol electrochemiluminescence (ECL) intensity for glucose quantification.
Main Results:
- Achieved a low detection limit of 0.1 μM for glucose.
- Demonstrated a linear response from 1.0 to 500.0 μM.
- Sensor showed excellent sensitivity, stability, and required only low power (∼3.2 V).
Conclusions:
- The developed multichannel bipolar electrochemiluminescence (BP-ECL) biosensor is a low-cost, simple, and fast solution for urine glucose detection.
- Its portability and low power requirements make it suitable for point-of-care testing and home-based health monitoring.
- This technology offers a feasible approach for daily monitoring of chronic diseases and primary healthcare screening.
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