Related Experiment Video
Updated: Apr 8, 2026
05:53
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
17.2K
Beyond age: Frailty-guided care in hematologic malignancies
Reed Friend1, P Connor Johnson2, Daphne Campbell3
1Division of Hematology, Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, North Carolina, USA.
Cancer
|April 7, 2026
Summary
Frailty assessment in blood cancers predicts treatment outcomes and toxicity. Integrating frailty measures improves care for vulnerable patients, enhancing benefits and quality of life.
Area of Science:
- Gerontology
- Hematology
- Oncology
Background:
- Frailty, a measure of physiological reserve, is distinct from chronological aging.
- Frailty predicts adverse outcomes such as toxicity, treatment discontinuation, and survival in hematologic malignancies.
Purpose of the Study:
- To synthesize current frailty assessment tools.
- To summarize evidence of frailty's impact in multiple myeloma, acute myeloid leukemia, and aggressive lymphomas.
Main Methods:
- Literature synthesis of contemporary frailty tools.
- Review of disease-specific evidence in key hematologic malignancies.
Main Results:
- Frailty assessment is crucial for predicting patient outcomes in hematologic cancers.
- Evidence highlights the role of frailty in multiple myeloma, AML, and lymphomas.
Conclusions:
- Integrating frailty measures into clinical practice can guide decision-making for vulnerable patients.
- Incorporating frailty assessment optimizes therapeutic benefits and enhances patient quality of life.
Related Concept Videos
02:56Treatment Resistant Cancers
3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
02:56Treatment Resistent Cancers
1.5K
1.5K
02:50Combination Therapies and Personalized Medicine
6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K
01:22Bone Marrow Sampling and Transplants
2.5K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.5K
01:25Continuing Care
2.1K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
2.1K
01:01Regulation of Hematopoietic Stem Cells
4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K