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Structure-bioactivity relationship in copper(II) complexes with new halogenated coumarin derivatives
Jakub Kurjan1, Zuzana Jendželovská2, Viktória Dečmanová2
1Department of Inorganic Chemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, Moyzesova 11, 041 54 Košice, Slovakia. ivan.potocnak@upjs.sk.
Dalton Transactions (Cambridge, England : 2003)
|April 7, 2026
Summary
New copper(II) complexes with coumarin-based ligands show significant cytotoxic activity against breast and colorectal cancer cells. Complexes 3, 4, and 7 are promising candidates for further antitumor research.
Area of Science:
- Coordination Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- Coumarin derivatives are known for their diverse biological activities.
- Copper complexes often exhibit enhanced pharmacological properties compared to their ligands.
- Developing novel metal-based anticancer agents is crucial for therapeutic advancements.
Purpose of the Study:
- To synthesize and characterize novel copper(II) complexes with coumarin-based ligands and their halogenated derivatives.
- To evaluate the cytotoxic and antitumor potential of these complexes against human cancer cell lines.
- To investigate the mechanism of action and biomedical properties of the most promising compounds.
Main Methods:
- Multistep organic synthesis of coumarin-based ligands (HL, 6-FHL, 6-ClHL, 6-BrHL).
- Preparation and characterization of nine copper(II) complexes using IR, NMR, mass spectroscopy, elemental analysis, and single-crystal X-ray diffraction.
- In vitro cytotoxic evaluation against MDA-MB-231 (breast) and HCT 116 (colorectal) cancer cell lines using IC50 values.
- Detailed in vitro antitumor studies including cell proliferation, viability assays, and flow cytometry.
- DNA-binding, human serum albumin interaction, antioxidant activity, and lipophilicity assessments.
Main Results:
- Nine new copper(II) complexes were successfully synthesized and characterized.
- Complexes 3, 4, and 7 demonstrated significant cytotoxic activity against tested cancer cell lines.
- In vitro studies revealed promising antitumor potential, including DNA interaction and antioxidant properties.
- Structural and stability analyses confirmed the integrity of the synthesized complexes.
Conclusions:
- The synthesized copper(II) complexes exhibit potent anticancer properties.
- Complexes 3, 4, and 7 are identified as lead compounds for further development as anticancer drugs.
- The study highlights the therapeutic potential of metal-based coumarin derivatives in oncology.
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