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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation
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Lipoic Acid-Intervened Decellularized Stem Cell Spheroid-Based Injectable Granular Gel for Diabetic Tissue

Tao Wang1,2, Haowei Fang3, Lili Qi1,2

  • 1Department of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine Tongji University, Shanghai, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 7, 2026
PubMed
Summary

This study developed a novel injectable biomaterial from engineered stem cell spheroids for diabetic tissue repair. The material effectively regenerated both skin and bone defects in diabetic rats.

Keywords:
decellularized matrixgranular gellipoic acidstem cell spheroidtissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Diabetic tissue defects present a significant challenge in regenerative medicine.
  • Existing tissue engineering scaffolds often lack sufficient bioactive components for effective repair.
  • Adipose-derived stem cells (ADSCs) hold potential but require functional enhancement for therapeutic applications.

Purpose of the Study:

  • To engineer adipose-derived stem cells (ADSCs) with lipoic acid (LA) to create enhanced stem cell spheroids (LA-SCS).
  • To develop an injectable, cell-free biomaterial from these engineered spheroids for diabetic tissue regeneration.
  • To evaluate the immunomodulatory and regenerative capabilities of the developed biomaterial in vitro and in vivo.

Main Methods:

  • Functional re-engineering of ADSCs with lipoic acid (LA) to form LA-intervened stem cell spheroids (LA-SCS).
  • Decellularization of LA-SCS to yield LA-intervened decellularized stem cell spheroids (LA-dSCS) to reduce immunogenicity.
  • Preparation of an injectable granular gel from LA-dSCS micro-particles leveraging their viscoelastic properties.
  • In vitro assessment of immunomodulatory effects on macrophages and in vivo evaluation in diabetic rat wound and cranial defect models.

Main Results:

  • LA-SCS exhibited enhanced paracrine activity and extracellular matrix (ECM) biosynthetic capacity.
  • LA-dSCS demonstrated potent immunomodulatory effects, promoting macrophage reprogramming, homeostasis, and autophagy.
  • The injectable LA-dSCS granular gel facilitated efficient preparation and application.
  • In vivo studies showed successful closure of both diabetic wound and cranial defects.

Conclusions:

  • A novel biomimetic engineering strategy was established by integrating cell-free bioactive aggregates with injectable granular gels.
  • This approach offers a promising proof-of-concept for the regeneration of complex diabetic tissue defects.
  • The developed LA-dSCS injectable material represents a potential therapeutic advancement for diabetic complications.