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Published on: April 19, 2021
umx version 4.5: Extending Twin and Path-Based SEM in R with CLPM, MR-DoC, Definition Variables, Ωnyx Integration,
Luis F S Castro-de-Araujo1,2, Nathan A Gillespie1, Michael C Neale1
1Virginia Institute for Psychiatric and Behavioral Genetics, https://ror.org/02nkdxk79Virginia Commonwealth University, USA.
Abstract:
Structural equation modeling (SEM) is a flexible statistical technique with multiple applications, including behavioral genetics and social sciences. Building on the original design of the umx package, which improved accessibility to OpenMx by specifying a concise syntax, umx v4.5 extends functionality for longitudinal and causal twin designs while improving interoperability with graphical modeling tools such as Onyx. New capabilities include: classic and modern cross-lagged panel models; Mendelian Randomization Direction-of-Causation (MR-DoC) twin models incorporating polygenic scores as instruments; support for definition variables directly in umxRAM(); a workflow for importing paths from Ωnyx; a dedicated function for incorporating censored variables' data into models, particularly valuable in biomarker research; improved covariate placeholder handling for definition variables; sex-limitation modeling across five twin groups, accommodating quantitative and qualitative sex differences; and covariate residualization in wide- or long-format data. These new functionalities accelerate reproducible, reliable, publication-ready twin and family modeling, and integrated journal-quality reporting, thereby lowering barriers to genetic epidemiological analyses.
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