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Super-resolution Fluorescence Microscopy

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

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Updated: Apr 8, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

Extending Near-Infrared Bioimaging Window Beyond 1500 nm.

Zi-Han Chen¹, Jiaxin Wu^1,2, Kui Yan¹

¹Department of Chemistry, College of Smart Materials and Future Energy, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Ichem, Fudan University, Shanghai, P. R. China.

Angewandte Chemie (International Ed. in English)

|April 7, 2026

Summary

This summary is machine-generated.

New luminescent materials enable advanced in vivo bioimaging beyond 1500 nm. This breakthrough offers deeper tissue penetration and higher resolution for biomedical applications.

Keywords:

bioimaging applications extended NIR region imaging technology luminescent materials superior bioimaging window

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Area of Science:

Biomedical Optics
Materials Science
In Vivo Imaging

Background:

Luminescent bioimaging is vital for in vivo visualization.
Wavelengths beyond 1500 nm offer reduced scattering and autofluorescence.
This enables enhanced tissue penetration and high-resolution imaging.

Purpose of the Study:

Review progress in bioimaging beyond 1500 nm.
Highlight novel luminescent materials for this spectral range.
Analyze applications and future directions.

Main Methods:

Summarized theoretical simulations of bioimaging windows (1500-1900 nm, 2100-2500 nm).
Reviewed design strategies for luminescent materials emitting beyond 1500 nm.
Analyzed in vivo bioimaging performance of these materials.

Main Results:

Identified optimal spectral regions for deep tissue imaging.
Detailed material design strategies including organic dyes, quantum dots, and lanthanide nanocrystals.
Demonstrated superior performance in volumetric and wide-field multiplexed bioimaging.

Conclusions:

Extended bioimaging windows beyond 1500 nm show significant promise.
Novel luminescent materials are key to unlocking this potential.
Further research is needed for clinical translation.