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Extending Near-Infrared Bioimaging Window Beyond 1500 nm
Zi-Han Chen1, Jiaxin Wu1,2, Kui Yan1
1Department of Chemistry, College of Smart Materials and Future Energy, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Ichem, Fudan University, Shanghai, P. R. China.
Angewandte Chemie (International Ed. in English)
|April 7, 2026
Summary
New luminescent materials enable advanced in vivo bioimaging beyond 1500 nm. This breakthrough offers deeper tissue penetration and higher resolution for biomedical applications.
Area of Science:
- Biomedical Optics
- Materials Science
- In Vivo Imaging
Background:
- Luminescent bioimaging is vital for in vivo visualization.
- Wavelengths beyond 1500 nm offer reduced scattering and autofluorescence.
- This enables enhanced tissue penetration and high-resolution imaging.
Purpose of the Study:
- Review progress in bioimaging beyond 1500 nm.
- Highlight novel luminescent materials for this spectral range.
- Analyze applications and future directions.
Main Methods:
- Summarized theoretical simulations of bioimaging windows (1500-1900 nm, 2100-2500 nm).
- Reviewed design strategies for luminescent materials emitting beyond 1500 nm.
- Analyzed in vivo bioimaging performance of these materials.
Main Results:
- Identified optimal spectral regions for deep tissue imaging.
- Detailed material design strategies including organic dyes, quantum dots, and lanthanide nanocrystals.
- Demonstrated superior performance in volumetric and wide-field multiplexed bioimaging.
Conclusions:
- Extended bioimaging windows beyond 1500 nm show significant promise.
- Novel luminescent materials are key to unlocking this potential.
- Further research is needed for clinical translation.
