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Updated: Apr 8, 2026
Mitochondria and Endoplasmic Reticulum Imaging by Correlative Light and Volume Electron Microscopy
Published on: July 20, 2019
Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex
Abdul Salam1, Goraksha T Sapkal1, Bodhidipra Mukherjee1
1School of Chemical Sciences, Indian Institute of Technology (IIT), Mandi, H.P.-175005, India. Chayan@iitmandi.ac.in.
None:
The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation are challenging. Here, we report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolved the smallest tubular diameter of the ER (110 nm) and quantified stress-induced morphological remodeling.
