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Related Concept Videos

Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Related Experiment Video

Updated: Apr 8, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Myocardial Strain in the Healthy Neonate.

Kerstin Magnusson1, Katarina Övermo Tydén1,2, Felicia Nordenstam1,2

  • 1Department of Pediatric Cardiology, Karolinska University Hospital, Stockholm, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|April 7, 2026
PubMed
Summary

Two-dimensional speckle tracking echocardiography (2DSTE) strain analysis is feasible in neonates. Myocardial strain increased significantly by 3-4 weeks, indicating improved cardiac function after birth.

Keywords:
echocardiographymyocardial strainneonatespeckle‐tracking

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Area of Science:

  • Cardiology
  • Neonatal Medicine
  • Medical Imaging

Background:

  • Conventional echocardiography has limitations in assessing neonatal cardiac function.
  • Two-dimensional speckle tracking echocardiography (2DSTE) derived strain can quantify systolic ventricular and atrial function.
  • Early detection of cardiac function changes is crucial in neonates, but reference data is scarce.

Purpose of the Study:

  • To describe myocardial strain in healthy neonates during the first day and at 3-4 weeks of age.
  • To evaluate the feasibility of 2DSTE in this population.
  • To establish reference values for neonatal myocardial strain.

Main Methods:

  • A cohort of 24 full-term neonates underwent echocardiographic examination twice.
  • Examinations were performed on the first day of life and at 3 weeks of age.
  • A specific echocardiographic protocol was followed to assess cardiac function and strain.

Main Results:

  • 2DSTE strain analysis was feasible in healthy neonates.
  • Right ventricular free wall strain, left ventricular global longitudinal strain, and atrial reservoir and conduit strain increased significantly by 3-4 weeks (p < 0.001).
  • Conventional right ventricular function measurements also showed improvement.

Conclusions:

  • Strain analysis using 2DSTE is a feasible method for quantifying neonatal cardiac function.
  • Increased myocardial strain at 3-4 weeks suggests improved systolic and diastolic function during circulatory adaptation.
  • This study provides valuable data on myocardial strain in healthy neonates.