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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Related Experiment Video

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Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control.

Lianghui Zhao1,2, Bin Guo1,2,3, Xiaoyun Dong1,2

  • 1Shandong University of Traditional Chinese Medicine, Jinan, China.

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|April 7, 2026
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Summary
This summary is machine-generated.

Quercetin-loaded liposomes effectively control myopia by inhibiting the hedgehog signaling pathway. This novel delivery system enhances quercetin bioavailability, offering a promising therapeutic strategy for myopia prevention.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Biotechnology

Background:

  • Myopia is a growing global health issue with increasing prevalence.
  • Current understanding of myopia pathogenesis and treatment requires further investigation.

Purpose of the Study:

  • To evaluate the therapeutic effect of quercetin in controlling myopia.
  • To elucidate the mechanism of action for quercetin in myopia treatment.

Main Methods:

  • Prepared quercetin-loaded liposomes (QLS) using thin-film dispersion and ultrasonication.
  • Assessed QLS efficacy in guinea pig models of form-deprivation myopia.
  • Investigated mechanisms via proteomics, western blotting, immunofluorescence, and molecular docking.
  • Evaluated biosafety through blood biochemical indexes and organ morphology.

Main Results:

  • QLSs demonstrated optimal particle size (274.06 ± 26.98 nm) and surface charge (-15.0 mV).
  • Liposomal formulation significantly improved quercetin's solubility and bioavailability, enabling low-dose efficacy.
  • QLSs showed sustained release, good in vivo biosafety, and inhibited hedgehog signaling pathway activation, reducing axial length elongation.

Conclusions:

  • QLSs effectively suppress experimental myopia progression by inhibiting the hedgehog signaling pathway.
  • This approach presents a promising strategy for myopia prevention and management.