A magnetically assisted titanium clip for colorectal lesion localisation: An ex vivo pre-clinical technical note

The objective of this study was to develop and evaluate a novel magnetic localisation clip for real-time magnetic detection of colorectal lesions in an ex vivo pre-clinical model.

A magnetic localisation clip incorporating a miniaturised neodymiumtings study magnet within a medical grade titanium structure was designed and optimised for mechanical stability, biocompatibility and consistent magnetic polarity. Ex vivo and benchtop experiments were performed to assess magnetic responsiveness, detection accuracy and mechanical performance. Clip stability was further evaluated under simulated peristaltic motion and following multiple sterilisation cycles.

The magnetic localisation clip exhibited stable attachment and a reliable magnetic response, allowing accurate localisation through up to 3-5 cm of soft tissue in the ex vivo model. The mean localisation time was below 55 s. No slippage or surface corrosion was observed after repeated mechanical stress or sterilisation. Compared with conventional dye injection and radiologic marking, the magnetic method provided rapid, radiation-free and repeatable localisation of target lesions.

The proposed clip demonstrated precise and stable localisation performance ex vivo, indicating potential for future intraoperative application pending in vivo validation.