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Reprogramming Cascade Catalysis via Protein-Directed Interfacial Assembly of Spatially Ordered Clusterzymes for

Fengjie Hao1, Juntao Hu1, Ziyu Kuai1

  • 1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.

ACS Applied Materials & Interfaces
|April 7, 2026
PubMed
Summary

Researchers developed protein-based nanoparticles (proteinosomes) with precisely arranged gold clusterzymes for enhanced cascade catalysis. These nanoparticles effectively scavenge reactive oxygen species (ROS) in vivo, offering potential for treating ROS-related diseases.

Keywords:
antioxidantcascadegold clusterzymesinterfacial self-assemblyproteinosomes

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