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Updated: Apr 9, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Development of Structurally Simplified, Non-azadecalin Glucocorticoid Antagonists which Demonstrate In Vivo Activity

Lorna A Duffy1, Mark T Mills1, Andrew W Phillips1

  • 1Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K.

Journal of Medicinal Chemistry
|April 7, 2026
PubMed
Summary

Researchers discovered new piperazine-based glucocorticoid receptor (GR) antagonists. These compounds, optimized using learnings from relacorilant, show promise for treating GR-related conditions.

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