Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

5.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
5.6K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.6K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.6K
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers01:27

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

1.9K
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
1.9K
Stimulants01:29

Stimulants

1.3K
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
1.3K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

2.0K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.0K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

5.5K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence-Enabled Prediction of Reversible Versus Irreversible Chemotherapy-Induced Myocardial Injury: Toward Precision Cardio-Oncology.

Cardiology in review·2026
Same author

Refractory ventricular tachycardia storm with 42 ICD shocks in 24 h: A case report.

Medicine international·2026
Same author

Cardiovascular Effects of Growth Hormone: From Deficiency to Acromegaly.

Cardiology in review·2026
Same author

Multiorgan involvement with cardiac, renal and skeletal manifestations following inhalation of compressed air: A case report.

Medicine international·2026
Same author

Coronary Collaterals: A Comprehensive Review.

Cardiology in review·2025
Same author

Regional variation in the incidence and outcomes of in-hospital cardiac arrest in the United States.

Circulation·2015

Related Experiment Video

Updated: Apr 9, 2026

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow
09:18

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow

Published on: December 15, 2023

3.7K

Caffeine and Cardiovascular Outcomes: Current Evidence and Clinical Perspectives.

Negarsadat Neshat1, William H Frishman2, Wilbert S Aronow2

  • 1From the Department of Medicine, Wellstar Kennestone Hospital, Marietta, GA.

Cardiology in Review
|April 7, 2026
PubMed
Summary

Caffeine

Keywords:
CYP1A2QTc prolongationadenosine receptor antagonismarrhythmiasatrial fibrillationblood pressurecaffeinecardiovascular diseasecardiovascular outcomescoffeecoronary artery diseaseenergy drinksheart failurehypertensionstroke

More Related Videos

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
09:11

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Published on: October 2, 2018

13.6K
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.7K

Related Experiment Videos

Last Updated: Apr 9, 2026

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow
09:18

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow

Published on: December 15, 2023

3.7K
Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
09:11

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Published on: October 2, 2018

13.6K
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.7K

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Nutritional Science

Background:

  • Caffeine is a widely consumed bioactive compound with complex cardiovascular effects.
  • Evidence on caffeine's cardiovascular impact is mixed, with some studies suggesting risks and others benefits.
  • Adenosine receptor antagonism by caffeine influences autonomic tone, vascular resistance, and heart rhythm.

Purpose of the Study:

  • To review the current evidence on caffeine's cardiovascular effects.
  • To evaluate the impact of different caffeine sources and consumption patterns.
  • To inform cardiovascular counseling regarding caffeine intake.

Main Methods:

  • Review of mechanistic, interventional, and epidemiologic studies on caffeine.
  • Analysis of randomized controlled trials and cohort studies.
  • Consideration of genetic variability and exposure patterns.

Main Results:

  • Acute caffeine intake can transiently increase blood pressure and alter sympathetic activity.
  • Habitual coffee consumption is linked to neutral or favorable cardiovascular outcomes, including reduced mortality.
  • Energy drinks and concentrated caffeine sources show more pronounced hemodynamic and electrophysiologic effects.
  • Evidence does not consistently support a proarrhythmic effect of habitual coffee consumption.
  • Recent trials question the need for caffeine restriction in conditions like atrial fibrillation.

Conclusions:

  • Caffeine's cardiovascular effects are dose-, source-, and patient-specific.
  • Universal caffeine restriction is not supported by current evidence.
  • A personalized approach is recommended for interpreting caffeine exposure in cardiovascular medicine.