Microplastics, nanoplastics and liver disease: an emerging health concern?

Human liver tissue has been found to contain microplastics and nanoplastics (MNPs), with evidence that hepatic MNP accumulation has markedly increased over the past 10 years, prompting critical questions regarding their potential causal role in liver disease. In cell-based and murine models, MNP exposure can trigger oxidative stress, fibrogenesis and inflammation, pathological features that resemble those of advanced liver disease, suggesting shared mechanistic pathways. Furthermore, the capacity for MNPs to act as vectors for microbial pathogens, antimicrobial resistance, endocrine-disrupting chemicals and carcinogenic additives might have important implications for liver pathology. This Perspective examines emerging evidence on the consequences of MNPs for liver health and disease, introducing the concept of plastic-induced liver injury. By highlighting critical methodological bottlenecks, key knowledge gaps and unmet research priorities, it lays out a road map for the emerging field of environmental hepatology.