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Automated Midline Shift and Intracranial Pressure Estimation based on Brain CT Images
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A novel algorithm for the continuous determination of individualized intracranial pressure (iICP) thresholds using a

Kevin Y Stein1,2, Logan Froese3, Amanjyot Singh Sainbhi4

  • 1Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada. steink34@myumanitoba.ca.

BMC Medical Informatics and Decision Making
|April 7, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Cerebrovascular reactivityIndividualized intracranial pressure thresholdsIntracranial pressurePersonalized medicine

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Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

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