Botulinum toxin for allergic rhinitis: a systematic review and meta-analysis of its therapeutic potential

Botulinum toxin type A (BTX-A) is emerging as a promising intervention for refractory allergic rhinitis. This study evaluates its effectiveness in treating refractory allergic rhinitis.

The primary outcome was total nasal symptom score (TNSS), while secondary outcomes included individual nasal symptom scores, quality of life (QOL), and adverse effects. Five trials involving 187 patients (mean age: 31.8 years) were included. BTX-A significantly improved TNSS at 4 weeks [SMD -2.07, 95% confidence interval (95% CI) -3.58 to -0.56; P  < 0.001] and 12 weeks (SMD -2.42, 95% CI -4.22 to -0.62; P  < 0.001). Neither comparison of BTX-A with triamcinolone injection nor oral cetirizine showed a significant difference in TNSS (SMD - 0.51, 95% CI -1.25 to 0.24; P  = 0.18 and SMD 0.50, 95% CI -0.07 to 1.06; P  = 0.08, respectively). In the BTX-A group, significant improvements were observed in rhinorrhea (SMD -2.18, 95% CI -3.74 to -0.62; P  < 0.001), sneezing (SMD -1.88, 95% CI -2.60 to -1.15; P  < 0.001), and itchiness (MD -1.57, 95% CI -2.45 to -0.69; P  < 0.001) at 4 weeks, with these effects persisting up to 12 weeks. No serious adverse events occurred following BTX-A administration.

BTX-A shows promise as an adjunctive therapy for refractory allergic rhinitis.