Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

8.1K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
8.1K
The Vestibular System01:29

The Vestibular System

45.3K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
45.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A fully inductive inference protocol for population GNNs in single-subject brain disorder diagnosis.

Computers in biology and medicine·2026
Same author

Precision-enhancing magnetic needle tracking system in ultrasound-guided fine needle aspiration of head and neck lesions: a novel image-guided technique.

Endocrine·2026
Same author

Non-destructive evaluation of microbial quality of beef (<i>M. longissimus thoracis</i> muscle) using visible/NIR hyperspectral imaging and machine learning methods.

Journal of animal science and technology·2026
Same author

Landmark-Guided Percutaneous Tracheostomy Without Visualization in Resource-Limited Settings.

The Laryngoscope·2026
Same author

Atrial Fibrillation, Brain Structure and Cognitive Function: A Mediation Analysis.

Korean circulation journal·2026
Same author

Head and neck squamous cell carcinoma following allogeneic bone marrow transplantation: Clinical features, genomic Alterations, and limited efficacy of palliative chemotherapy.

Oral oncology·2025

Related Experiment Video

Updated: Apr 9, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

649

Vestibular-Visual Reweighting in Persistent Postural-Perceptual Dizziness: A Multilevel Resting-State fMRI Study.

Jin-Ju Kang1,2, Yongseon Yoo3, Sang-Yeon Kim1

  • 1Department of Neurology, Jeonbuk National University Hospital and School of Medicine, Jeonju, Republic of Korea.

Neural Plasticity
|April 8, 2026
PubMed
Summary

Persistent postural-perceptual dizziness (PPPD) is a functional vestibular disorder lacking objective markers. This study reveals altered brain network connectivity in PPPD patients, linking visual-cerebellar network changes to symptoms and psychological factors.

Keywords:
ALFF/fALFF biomarkerbrainstem–cerebellar dysconnectivityfunctional network connectivitymultisensory integrationpersistent postural-perceptual dizzinessresting-state functional MRIvisual-cerebellar coupling

More Related Videos

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.9K
Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT
08:57

Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT

Published on: March 3, 2023

2.5K

Related Experiment Videos

Last Updated: Apr 9, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

649
Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.9K
Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT
08:57

Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT

Published on: March 3, 2023

2.5K

Area of Science:

  • Neuroscience
  • Functional Neuroimaging
  • Vestibular Disorders

Background:

  • Persistent postural-perceptual dizziness (PPPD) is a common yet poorly understood functional vestibular disorder.
  • It causes chronic dizziness and unsteadiness, significantly impacting daily life.
  • Currently, PPPD lacks objective neurobiological markers for diagnosis.

Purpose of the Study:

  • To identify objective neurobiological markers for PPPD using multimodal neuroimaging.
  • To investigate functional brain network alterations in patients with PPPD compared to healthy controls.
  • To correlate brain network findings with clinical symptoms and psychological factors in PPPD.

Main Methods:

  • Resting-state functional MRI (rs-fMRI) was performed on 52 PPPD patients and 50 healthy controls.
  • Data analyzed using independent component analysis (ICA-FNC), amplitude of low-frequency fluctuations (ALFF/fALFF), and seed-based connectivity.
  • Regions of interest included vestibular, subcortical, and visual network areas.

Main Results:

  • Observed increased connectivity in cerebellar (CB) and visual (VIS) networks.
  • Found reduced connectivity between brainstem-cerebellar (BSC) and vestibular/oculomotor/default-mode networks.
  • Decreased ALFF in vestibular integration areas contrasted with increased fALFF in other cortical regions.
  • Strengthened thalamo-VIS, striato-limbic, and nodulus-hippocampal connectivity noted.
  • Increased BSC-VIS coupling correlated with depression, anxiety, and reduced balance confidence.

Conclusions:

  • PPPD exhibits a multiscale neurobiological signature characterized by vestibular cortical disengagement.
  • Maladaptive visual-cerebellar network reinforcement is implicated in PPPD pathophysiology.
  • Network-level markers show potential as adjuncts for diagnosing PPPD and understanding its biopsychosocial phenotype.