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Updated: Apr 9, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Optimizing Obesity Management With GLP-1 Agonist Medication Through Mobile Health Technology, Nutrition Therapy, and
Elizabeth Sharp Edens1, Heather Falise1, Rebecca Smith1
1TouchCare Method, Health Meets Wellness, Bucks Health and Wellness New York New York USA.
Background:
GLP-1 RAs are effective in treating obesity; however, they typically result in significant loss of skeletal muscle mass. Real-world evidence to inform systematic guidelines and clinical implementation for preserving skeletal muscle mass and reducing cardiometabolic risk with lifestyle modifications on GLP-1 RAs remains limited.
Objective:
This study evaluated the effectiveness of the TouchCare Method, a lifestyle intervention incorporating nutrition and exercise with GLP-1 RAs, for improving body composition and cardiometabolic risk.
Methods:
A retrospective chart review included patients enrolled in Bucks Health and Wellness between February 2024 and September 2025, for at least 12 month (n = 187). The TouchCare Method incorporates registered dietitian counseling, progressive exercise programming, mobile self monitoring, and body composition analysis during visits. Primary outcomes included: clinically significant weight loss (> 10% of body weight), proportion of weight loss from skeletal muscle mass, and changes in total-C, LDL-C, Apolipoprotein B, Triglycerides, HbA1c, and blood pressure at 12 months.
Results:
Patients adherent to the TouchCare Method for 12 months were included in the final analysis (n = 171). Clinically significant weight loss (≥ 10%) was achieved by 69.56% (n = 139) of patients. Skeletal muscle mass accounted for 12.22% ± 8.73% of total weight loss. Among prediabetic patients (n = 95), 74.7% (n = 71) reached euglycemia by 12 months. Patients with Stage II hypertension or higher (77% of the cohort) demonstrated improved blood pressure control, with most reaching < 140/90 mmHg. Patients with HLD experienced significant reductions in Total-C (24.71 ± 23.31 mg/dL), LDL-C (-13.75 ± 21.51 mg/dL), and ApoB (-14.24 ± 16.19 mg/dL). All lipid and HgA1c changes were statistically significant (p < 0.001).
Conclusion:
The TouchCare Method may improve GLP-1 RA treatment outcomes by providing comprehensive structured lifestyle interventions supporting clinically significant weight loss while preserving skeletal muscle mass and improving cardiometabolic risk factors.
Insights
The TouchCare Method, combining nutrition and exercise with GLP-1 RAs, aids significant weight loss while preserving muscle mass and improving cardiometabolic health.
Area of Science:
- Metabolic Health and Endocrinology
- Obesity and Weight Management
- Cardiovascular Risk Reduction
Background:
- Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective for obesity treatment but often cause substantial skeletal muscle mass loss.
- Limited real-world data exists on lifestyle interventions to preserve muscle mass and mitigate cardiometabolic risks during GLP-1 RA therapy.
Purpose of the Study:
- To evaluate the TouchCare Method, a lifestyle intervention, in conjunction with GLP-1 RAs.
- To assess the impact of the TouchCare Method on body composition and cardiometabolic risk factors.
Main Methods:
- Retrospective chart review of 187 patients using the TouchCare Method (nutrition, exercise, self-monitoring) with GLP-1 RAs for at least 12 months.
- Primary outcomes: ≥10% weight loss, skeletal muscle mass proportion of weight loss, and changes in lipids, HbA1c, and blood pressure.
Main Results:
- 69.56% of patients achieved clinically significant weight loss (≥10%); skeletal muscle loss was 12.22% ± 8.73% of total weight loss.
- Significant improvements observed in glycemic control (74.7% of prediabetics reached euglycemia), blood pressure, and lipid profiles (Total-C, LDL-C, ApoB) (p < 0.001).
Conclusions:
- The TouchCare Method, a structured lifestyle intervention, may enhance GLP-1 RA efficacy.
- This approach supports significant weight loss, preserves skeletal muscle mass, and improves cardiometabolic risk factors.
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