Related Experiment Video
Updated: Jul 1, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
Published on: January 6, 2011
Cognitive and affective Theory of Mind abilities in Parkinson's disease before and 1 year after subthalamic deep
Anna Elsenbach1, Melanie Astalosch1, Luísa Martins Ribeiro1
1Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Background:
Parkinson's disease (PD) is associated with specific cognitive deficits and dysfunctions in Theory of Mind (ToM), which can impact patients' quality of life. ToM refers to the ability to infer the mental and emotional state of one's counterpart and involves the prefrontal cortex and the basal ganglia in its function. While bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in PD significantly improves motor symptoms, little is known about its effects on ToM.
Methods:
We prospectively applied an adapted version of the Yoni ToM paradigm, the Montréal Cognitive Assessment (MoCA), and an extensive tablet-based neurocognitive test set (CANTAB Connect™) before and 1 year after DBS surgery. Wilcoxon signed-rank tests were performed for comparisons of pre- and postoperative results, and Spearman's correlations assessed the association between parameters with consequent Bonferroni corrections for multiple comparisons.
Results:
A total of 27 PD patients who received bilateral STN-DBS at Charité Universitätsmedizin Berlin between June 2019 and September 2021 were included in the study. Among these patients, 21 (77.8%) were men, with an average age of 58.7 ± 10.1 years and a disease duration averaging 10.2 ± 5.0 years. ToM abilities remained stable 1 year after DBS surgery and were associated with overall cognitive function and several specific neuropsychological domains, including reaction time, visual learning, and multitasking performance.
Conclusion:
Our findings suggest that specific ToM abilities and overall cognitive performance remain largely stable 1 year following STN-DBS. Performance on ToM tasks appears to be linked to individual cognitive profiles.
Related Concept Videos
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

