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Updated: May 7, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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The impact of cardiometabolic multimorbidity on cognitive function in older adults: a review

Huan Liu1, Junxiang Sun1, Ting Wang1

  • 1Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Public Health
|April 8, 2026
PubMed

Insights

Cardiometabolic multimorbidity (CMM) significantly accelerates cognitive decline and dementia in older adults. This review synthesizes CMM

Area of Science:

  • Gerontology
  • Neurology
  • Cardiology

Background:

  • Cardiometabolic multimorbidity (CMM) is a prevalent chronic condition.
  • CMM is strongly linked to cognitive impairment and dementia progression.
  • Current research on cognitive function in CMM is limited, especially in older adults.

Purpose of the Study:

  • To review the impact of CMM on cognitive function in older adults.
  • To synthesize current knowledge on the correlation between CMM and cognitive impairment.
  • To explore underlying mechanisms, assessment tools, and risk factors for cognitive dysfunction in CMM.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies focusing on cardiometabolic diseases and cognitive function.
  • Examination of data on older adults with multiple cardiometabolic conditions.

Main Results:

  • CMM is a significant driver of cognitive dysfunction and dementia.
  • Existing studies often overlook the complex interplay of multiple cardiometabolic diseases.
  • Specific correlations, mechanisms, and risk factors require further investigation.

Conclusions:

  • CMM poses a substantial threat to cognitive health in aging populations.
  • There is a critical need for comprehensive understanding and management of CMM to prevent cognitive decline.
  • Insights gained can inform screening and management strategies for high-risk individuals.

Keywords:
cardiometabolic multimorbiditycognitive functionimpactolder adultsreview

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