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Related Experiment Video

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Transbronchoscopic Local Injection of Triamcinolone Acetonide for Subglottic Granulation Tissue: A Case Report.

Keigo Sudo1, Kentaro Minegishi1, Takaya Sato1

  • 1Department of Thoracic Surgery Saitama Medical Center Jichi Medical University Saitama Japan.

Respirology Case Reports
|April 8, 2026
PubMed
Summary
This summary is machine-generated.

Subglottic granulation tissue can cause airway stenosis. Local triamcinolone acetonide injection after surgical resection effectively prevented recurrence in a young woman, offering a safe, minimally invasive treatment for this rare condition.

Keywords:
subglottic granulation tissuetransbronchoscopic local injectiontriamcinolone acetonide

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Area of Science:

  • Pulmonology
  • Otolaryngology
  • Medical Therapeutics

Background:

  • Subglottic granulation tissue is a rare, recurrent cause of airway stenosis following epithelial injury.
  • Endotracheal intubation is a common cause of such injury, leading to progressive dyspnea.

Purpose of the Study:

  • To report a case of recurrent subglottic granulation tissue successfully treated with transbronchoscopic triamcinolone acetonide injection.
  • To evaluate the efficacy and safety of this minimally invasive approach.

Main Methods:

  • A 19-year-old woman with dyspnea post-intubation underwent bronchoscopic resection of a subglottic mass.
  • Recurrence was treated with repeat resection and local injection of triamcinolone acetonide (TA).
  • Follow-up included bronchoscopic surveillance over 4 months.

Main Results:

  • Initial resection of granulation tissue was followed by rapid recurrence.
  • Second resection combined with local TA injection resulted in no recurrence during 4 months of follow-up.
  • Triamcinolone acetonide demonstrated anti-inflammatory and antifibrotic effects locally.

Conclusions:

  • Transbronchoscopic triamcinolone acetonide injection is a safe and effective treatment for recurrent airway granulation lesions.
  • This minimally invasive method provides targeted drug delivery with minimal systemic toxicity.
  • Few similar cases have been reported, highlighting the novelty of this approach.