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Related Experiment Video

Updated: Apr 9, 2026

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
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Facial Overfilled Syndrome: A Narrative Clinical Review.

Changyang Zhou1, Qilei Che2,3,4, Ruonan Zhao2,3,4

  • 1Department of Dermatology, North Sichuan Medical College, Nanchong, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|April 8, 2026
PubMed
Summary
This summary is machine-generated.

Facial Overfilled Syndrome (FOS) is a growing complication from excessive dermal fillers, causing facial distortion and distress. Early prevention and precise, individualized treatment are key to managing this condition.

Keywords:
dermal filler complicationsfacial overfilled syndromefacial overfillingoverfilled face

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Plastic Surgery

Background:

  • Facial Overfilled Syndrome (FOS) is an iatrogenic complication from excessive or improper dermal filler use.
  • It leads to facial distortion, unnatural animation, and significant psychological distress.
  • Aesthetic perception biases can complicate the clinical presentation and patient expectations.

Purpose of the Study:

  • To provide a comprehensive review of Facial Overfilled Syndrome (FOS).
  • To outline the etiology, clinical features, diagnostic methods, and management strategies for FOS.
  • To emphasize prevention through anatomical knowledge and tailored treatment plans.

Main Methods:

  • A narrative clinical review was performed.
  • Literature search conducted in PubMed, Google Scholar, and CNKI.
  • Keywords included "facial overfilled syndrome", "facial overfilling", "overfilled face", and "dermal filler complications" up to October 2025.

Main Results:

  • FOS pathogenesis involves anatomical mismatch, biomechanical issues, and cumulative filler effects.
  • Clinical signs include resting distortion and unnatural facial animation.
  • Ultrasound-guided hyaluronidase is the gold standard for HA fillers; adjunctive therapies require caution.

Conclusions:

  • Management requires a shift towards precision, layer-specific augmentation.
  • Prevention is paramount, emphasizing patient education and anatomical expertise.
  • Future research should focus on filler degradation, 3D assessment, and reversible biomaterials.