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Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Related Experiment Video

Updated: Jul 6, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

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Posterior-Only Vertebral Column Resection for Neglected Post-traumatic Thoracolumbar Fracture-Dislocation With

Reyaz Ahmed1, Abhishek Raina2, Sumit Mishra1

  • 1Orthopaedics, Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Medical College and Hospital, Srinagar, IND.

Cureus
|April 8, 2026
PubMed
Summary

Severe neglected thoracolumbar fractures can cause rigid deformities. A posterior-only vertebral column resection effectively corrected a patient's deformity and improved neurological function.

Area of Science:

  • Orthopedics
  • Neurosurgery
  • Spinal Surgery

Background:

  • Neglected post-traumatic thoracolumbar fracture-dislocations can lead to severe rigid kyphotic deformity.
  • These deformities often result in sagittal imbalance, chronic pain, and delayed neurological deficits.
Keywords:
adult spinal deformityneglected spinal injuryneurological recoverypost-traumatic kyphosispost-traumatic spinal deformityreconstructive surgical proceduressagittal balancespinal fusionthoracolumbar fracture-dislocationvertebral column resection

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