Related Experiment Video
Updated: Jun 15, 2026
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Measurement of functional mobility in multiple sclerosis: A crosswalk between the patient-determined disease steps
Alexa S Gonzalez1, Joshua M Garcia1, Eric Engebretson2
1Department of Psychology, University of Houston, Houston, TX, USA.
Background:
The Patient-Determined Disease Steps (PDDS) and Neuro-QoL Lower Extremity Function-Short Form (Neuro-QoL LEF-SF) are patient-reported outcome measures used to monitor mobility symptoms in multiple sclerosis (MS).
Objective:
To develop and validate a crosswalk between the PDDS and Neuro-QoL LEF-SF.
Methods:
Using equipercentile equating, we created a crosswalk from a training sample of 619 MS patients (mean PDDS = 2.4 ± 2.3; mean Neuro-QoL LEF-SF = 33.0 ± 8.3). Validation was performed in a separate sample of 147 MS patients (mean PDDS = 0.6 ± 1.2; mean Neuro-QoL LEF-SF = 38.9 ± 2.8). Agreement between original and converted scores was evaluated using paired t-tests and concordance correlation coefficients.
Results:
PDDS and Neuro-QoL LEF-SF scores were strongly correlated in both training (r = -0.89) and validity (r = -0.76) samples. No significant differences in change scores were observed. Concordance coefficients of original and converted scores supported good to very good agreement.
Conclusion:
We developed a crosswalk for the conversion of scores between the PDDS and the Neuro-QoL LEF-SF for patients with MS. Evidence for the preliminary validity of this crosswalk was demonstrated with both the initial training sample and a separate validity sample. This crosswalk facilitates score comparisons and data harmonization across studies and clinical registries using either measure.
