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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Prognostic Determinants in De Novo Sinonasal Squamous Cell Carcinoma: A Retrospective Study
Yue Li1, Lili Cao1, Jing Zhou1
1Department of Otolaryngology-Head and Neck Surgery, Key Laboratory of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University Beijing China.
Objective:
Patients diagnosed with de novo sinonasal squamous cell carcinoma (DN-SSCC) generally present at an advanced stage and have a poor prognosis. The study aimed to summarize and analyze the outcomes of DN-SSCC patients.
Study Design:
Retrospective cross-sectional study.
Setting:
Single-center clinical database.
Methods:
Overall survival was assessed with Kaplan-Meier analyses and Cox proportional hazard regression analyses for patients diagnosed with DN-SSCC between 2010 and 2018.
Results:
Long-term follow-up was completed for 85 out of 112 patients. The distribution of cancer stages was as follows: 1.8% in stage Ⅰ, 7.1% in stage Ⅱ, 23.2% in stage Ⅲ, and 67.9% in stage Ⅳ. Ocular invasion was present in 50.9% and intracranial invasion in 23.2%. Significant intergroup differences in T-stage (P = .009) and clinical stages (P = .028) across therapeutic modalities. The 1-year and 5-year overall survival (OS) rates were 83.5% and 51.4%, respectively. Factors significantly associated with prognosis included age (P = .048), lymph node classification (P = .003), clinical stages (P = .002), ocular invasion (P = .035), therapeutic modalities (P < .001), and resection margin status (P = .005). Surgery followed by adjuvant chemotherapy or/and radiotherapy (Surgery + CT/RT) demonstrated best prognosis, with a 5-year OS rate of 71.9%. Margin status significantly impacted survival outcomes (5-year OS: 56.0% negative margin versus 29.0% positive margin) (log-rank P = .005). Lymph node classification (HR 4.927, 95% CI 1.296-18.733; P = .019) and preoperative induction chemotherapy combined with surgery (ICT + Surgery) (HR 0.048, 95% CI 0.004-0.574; P = .017) were independent prognostic factors for DN-SSCC.
Conclusions:
Patients receiving Surgery + CT/RT had better prognoses. This therapeutic modality is recommended for advanced-stage patients, especially those with positive resection margins.
