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Updated: Jun 14, 2026
Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model
Published on: November 13, 2012
A Case of Pediatric Spitz Melanoma With a ZEB2::ALK Fusion
Nathanael C Jensen1, Shadai Gociman1, Sarah D Cipriano1
1Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
Abstract:
We present a rare case of Spitz melanoma in a 3-year-old male patient with a ZEB2::ALK fusion. This ALK-fused tumor exhibited aggressive behavior, recurring after an initial wide local excision and progressing despite neoadjuvant immunotherapy with a PD-1 inhibitor. Following a second surgical resection and adjuvant radiation therapy, the patient was started on adjuvant targeted therapy with lorlatinib, an ALK kinase inhibitor. This report illustrates the role of immunotherapy and targeted therapy in melanoma treatment.
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