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Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein as Treatment for Gout Flare
Jiao Luo1,2, Zhongming Xie1,2, Weizhong Zhang1,2
1Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, P.R. China.
Objectives:
A single-center, prospective, random, open-label study of acute gout patients treated with etanercept.
Methods:
The treatment protocol involved subcutaneous administration of etanercept at a dose of 25 mg twice in five days. The control group received 20 mg of methylprednisolone administered intravenously every day for a total of five days. Baseline assessments, conducted at the initiation of etanercept included visual analogue scale (VAS) scores and C-reactive protein (CRP) levels. The levels of CRP and VAS in the gout patient after being injected with etanercept or methylprednisolone for 5 days. Adverse events were diligently recorded throughout the study period.
Results:
Etanercept demonstrated rapid and substantial alleviation of pain and inflammatory responses in all 12 acute gout patients. Its effect is comparable to that of methylprednisolone.
Conclusion:
Etanercept might be contemplated for "off-label" use in gout patients who do not respond to standard therapy or glucocorticoid therapy, encounter severe side-effects and contraindications.
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