Diallyl disulfide reduces oxidative stress to mitigate uranium tailings radiation-induced damage to the hematopoietic...

The blood system is sensitive to radiation, making it vulnerable to damage. Diallyl disulfide (DADS), a primary bioactive compound derived from allicin degradation, has shown significant potential in tumor prevention and treatment. This study investigates the role and mechanisms of DADS in mitigating radiation-induced damage to the blood system, thereby providing both experimental evidence and theoretical insights for further research on radiation damage protection. A C57BL/6J mouse model was exposed to low-dose ionizing radiation and treated with DADS; spleen red pulp area, bone marrow morphology, peripheral blood indices, and erythropoietin levels were addressed. In addition, a GM12878 human B lymphocyte cell model was used to evaluate the effects of DADS on cell viability and apoptosis during irradiation. Our results show that DADS reduces radiation-induced damage both in mouse and GM12878 cell models. Specifically, DADS shields GM12878 cell apoptosis from radiation by reducing reactive oxygen species (ROS) production, thereby exerting a protective effect on the radiation damage to the blood system. Our findings underscore the potential of DADS as a protective agent against radiation-induced damage to the blood system.