Association Between Periodontitis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional...

Area of Science:

• Internal Medicine
• Periodontology
• Hepatology

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern.
• Periodontitis, a common oral inflammatory condition, has been implicated in systemic diseases.
• The relationship between periodontitis and MASLD, especially considering sex differences, requires further investigation.

Purpose of the Study:

• To investigate the association between periodontitis and MASLD.
• To explore potential sex differences in this association.
• To analyze the influence of age and hormonal changes in women on the periodontitis-MASLD link.

Main Methods:

• A cross-sectional study included participants aged 40-74 years.
• Logistic regression analyses were performed to assess the association between periodontitis and MASLD.
• Stratified analyses by sex and age groups for women were conducted, along with interaction analyses.

Main Results:

• Periodontitis was significantly associated with an increased odds of MASLD in women (OR=1.40-1.64).
• This association was most pronounced in women aged 50-59 years.
• A significant multiplicative interaction between sex and periodontitis indicated differing risk patterns for MASLD between men and women.

Conclusions:

• Periodontitis is associated with MASLD in women, particularly in the 50-59 age group.
• The findings suggest that the relationship between periodontitis and MASLD is sex-dependent.
• Further research is warranted to elucidate the mechanisms underlying these sex differences.